litaba

Bakeng sa tlhokomelo e sebetsang ea letlalo, ha e le hantle, ho ke ke ha qojoa ho ba le maikutlo a itseng a metsoako, eseng feela ho khothalletsa sehlahisoa, empa le lisebelisoa tsa sehlahisoa. Kajeno, ha re bue ka "carnosine" ea metsoako ea lihlahisoa tsa tlhokomelo ea letlalo.

"Carnosine" ke eng?
Carnosine ke dipeptide e entsoeng ka beta-alanine le L-histidine, e nang le litaba tse ngata tsa mesifa le bokong. Carnosine e na le li-antioxidant tse phahameng 'me e ka senya li-radicals tsa mahala' meleng.

Kamoo 'carnosine' e sebetsang kateng
Carnosine e ka eketsa khanyetso ea letlalo, ea boloka boemo ba bocha ba lisele ka ho boloka tšebetso ea lisele ka har'a sehlopha se felletseng sa spectrum le maemo a mahala a radical, ho khothaletsa tlhahiso ea collagen, le ho boloka letlalo le reketla.

Karolo ea 'carnosine'
Carnosine e ka eketsa khanyetso ea letlalo, ea boloka boemo ba bocha ba lisele ka ho boloka tšebetso ea lisele ka har'a sehlopha se felletseng sa spectrum le maemo a mahala a radical, ho khothaletsa tlhahiso ea collagen, le ho boloka letlalo le reketla. Boemo ba lik'hemik'hale tsaL-carnosineke ho thehoa ha beta-alanine le L-histidine ka ketso ea carnosine synthase. Carnosine e na le litebello tse pharaletseng tsa ts'ebeliso litabeng tsa bongaka, tlhokomelo ea bophelo bo botle le bohloeki ka lebaka la thepa ea eona ea antioxidant, litlamorao tsa mahala tsa scavenging, chelation e nang le litšepe tsa phetoho, neuroprotection, nts'etsopele ea pholiso ea maqeba, le anti-botsofali.

1. Tšebeliso ea carnosine indastering ea lijo
Karolo e ka sehloohong ea oli lijong ke motsoako oa li-glycerides tse fapaneng tsa mafura. Ka lebaka la karabelo ea mahala ea radical ea unsaturated fatty acid glycerides nakong ea polokelo, li-peroxide le li-aldehyde tse nkhang hamonate kapa li-carboxylic acid tse nang le liketane tse khutšoane tsa khabone lia hlahisoa. Ka hona, ho ja lijo tse nang le li-peroxide tse mafura ho tla ntšetsa pele lipid peroxidation 'meleng ea batho le ho baka mafu a fapaneng. Ka hona, butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, joalo-joalo hangata e sebelisoa ho lokisa lijo le polokelo ho thibela peroxidation ea mafura, empa katleho ea bona e tla fokotseha ha ho futhumala ha lijo, 'me e na le chefo e itseng. L-carnosine ha e khone ho thibela oxidation ea mafura feela, empa hape e na le ts'ireletso e phahameng le mesebetsi ea tlhokomelo ea bophelo. Ka hona, L-carnosine ke antioxidant ea bohlokoa le e loketseng ea lijo.
2. Tšebeliso ea carnosine meriana le tlhokomelo ea bophelo bo botle
(1) Carnosine le Antioxidant

Carnosine e ke ke ea sebelisa feela lesale la imidazole N athomo le peptide bond N athomo ka masala a histidine ho chelate tšepe ion le ho thibela oxidation ea mafura e bakoang ke li-ion tsa tšepe, empa hape le histidine e lehlakoreng la ketane ea carnosine e na le bokhoni ba ho hapa li-radicals tsa hydroxyl. E ka thibela oxidation ea mafura e bakoang ke li-ion tse seng tsa tšepe. Ka hona, joalo ka ntho e sebetsang e mengata ea antioxidant, carnosine e ka sireletsa lera la sele ka mokhoa o tsitsitseng 'me ke mokelikeli oa mahala o qhibilihang ke metsi. , e ka thibela peroxidation ea lera la sele. Ha ho bapisoa le li-antioxidants tse ling tsa tlhaho tse kang VC, carnosine e na le matla a matla a antioxidant. Ntle le ho thibela ts'ebetso ea peroxidation ea lera la sele, carnosine e ka boela ea thibela letoto la liketso tse ling tsa intracellular peroxidation, ke hore, carnosine e ka thibela mohato o mong le o mong oa karabelo ea oxidation ka har'a ketane eohle ea peroxidation nthong e phelang. Karolo ea li-antioxidants tse kang VC ke ho thibela li-radicals tsa mahala hore li se ke tsa kena ka har'a lisele, ke hore, li ka thibela feela ts'ebetso ea "peroxidation" ea mokelikeli oa membrane ea sele, 'me e ke ke ea etsa letho bakeng sa li-radicals tsa mahala tse keneng ka seleng.
(2) Carnosine le seso sa ka mpeng

Peptic ulcer ke lefu la lefats'e le sa foleng la tšilo ea lijo, 'me lintlha tse tobileng tse bakang liso ha li hlake hantle hajoale, empa pathology e lumela hore lintho tse mabifi (joalo ka gastric acid, secretion ea pepsin, tšoaetso ea Helicobacter pylori) le thibelo kapa cellular e bakoang ke ho se leka-lekane ha lintho tse sireletsang (mucus secretion, bicarbonate secretion, tlhahiso ea prostaglandin). Mokhoa oa tlhaho o sireletsang mpa ke: o etsa lera le teteaneng la mucosa ea gastric e sebetsang e le thibelo e sireletsang ho sireletsa lisele tse ka har'a lesela. Ho boloka lera la mucous le ntse le tsoela pele ho sireletsa mpa, empa secretion e feteletseng e ka baka liso tsa ka mpeng. Liphuputso li fumane hore zinki-carnosine e nkiloeng ka lijo e ka thibela liso ka katleho, e ka boloka botšepehi ba mpa le mokhoa oa eona oa tlhaho oa tšireletso, sena se bakoa ke thepa ea antioxidant ea carnosine, ho tsitsisa lera, taolo ea thepa ea Pharmacological ea ho itšireletsa mafung le ho lokisa lisele. Ho ea ka liteko tsa meriana, ka mor'a ho nka zinc-carnosine libeke tse robeli, 70% ea bakuli ba ileng ba noa moriana ba bontšitse ntlafatso e kholo, 'me karolo ea 65 lekholong ea liso tsa ka mpeng e ile ea ntlafatsoa ka gastroscopy.
(3) Carnosine le taolo ea 'mele ea ho itšireletsa mafung

Karabelo ea 'mele ea ho itšireletsa mafung ke ts'ebetso ea fisioloji e bolokang homeostasis mme e laoloa ke lintho tse sebetsang tsa 'mele linthong tse phelang. Li-immunomodulators li bua ka phekolo ea sehlopha sa mafu a bakoang ke ho se sebetse ha 'mele oa ho itšireletsa mafung,' me e sebelisetsoa ho tsosolosa karabelo ea 'mele ea ho itšireletsa mafung, ho thibela ho fokotseha ho sa tloaelehang kapa ho hatella karabelo ea eona e potlakileng. Boholo ba li-immunomodulators tse teng li entsoe ka mekhoa ea ho kopanya lik'hemik'hale, tse nang le litlamorao tse itseng tse chefo le tse mpe. Liphuputso li bontšitse hore carnosine e na le ts'ebetso ea immunomodulatory, 'me ke eona feela ntho e sebetsang ea physiologically e fumanoang ho fihlela joale bakeng sa immunomodulation,' me e 'nile ea sebelisoa haholo ho phekola mafu a sa tšoaneng a ho itšireletsa mafung le mafu a bakoang ke ho itšireletsa mafung a sa tloaelehang.