Lihlahisoa tsa Motho 2, 5-Dimethoxybenzaldehyde CAS 93-02-7

Re ikemiseditse ho fana ka tshebeletso e bonolo, e bolokang nako le ho boloka tjhelete e le nngwe feela bakeng sa bareki bakeng sa Dihlahiswa tsa Motho 2, 5-Dimethoxybenzaldehyde CAS 93-02-7, Khamphani ya rona e lebeletse ka tjantjello ho theha maqhama a nako e telele le a monate a balekane ba dikgwebo tse nyane le bareki le borakgwebo ho tswa hohle lefatsheng lohle.
Re ikemiselitse ho fana ka litšebeletso tse bonolo, tse bolokang nako le tse bolokang chelete hang-hang bakeng sa bareki.93-02-7 le 2 5-Dimethoxybenzaldehyde, Re latela mokhoa o phahameng oa ho sebetsana le lihlahisoa tsena tse netefatsang ho tšoarella ka ho fetisisa le ho tšepahala ha lihlahisoa. Re latela mekhoa ea morao-rao e sebetsang ea ho hlatsoa le ho otlolla e re lumellang ho fana ka boleng bo ke keng ba lekanngoa ba lihlahisoa bakeng sa bareki ba rona. Re lula re hahamalla phetheho 'me boiteko bohle ba rona bo lebisitsoe molemong oa ho fumana khotsofalo e felletseng ea bareki.

2,5-Dimethoxybenzaldehyde ke phofo e khanyang ea kristale e mosehla e boima ba molek'hule ea 166.18 le ntlha e belang ea 146 ° C. E qhibiliha ka har'a metsoako ea tlhaho e kang ethanol le ether. E sebelisoa haholo-holo e le setsi sa meriana.

Ntle le ho ba oxidized kapa ho fokotsoa ho 2,5-dimethoxybenzoic acid, benzonitrile kapa benzyl joala, 2,5-dimethoxybenzaldehyde ka boeona le eona e na le boleng bo ikhethang ba ts'ebeliso. Ka ho sebetsana le lintho tse nang le mefuta e fapaneng ea lihlopha tse sebetsang, limolek'hule tsa lithethefatsi tse nang le mekhoa e fapaneng le liphello tse fapaneng li ka fumanoa. Boloetse ba Parkinson (PD) ke lefu le tloaelehileng la neurodegenerative, 'me matšoao a lona a mantlha a kenyelletsa ho thothomela ha mesifa, ho satalla, mathata a ho sisinyeha, boemo ba 'mele le mathata a ho leka-lekanya ho sisinyeha. Ntlafatso e eketsehileng e tla boela e lebise tlhokomelo, temoho, mathata a ho hopola le 'dementia' e totobetseng. Hajoale, kalafo ea PD e kenyelletsa haholo kalafo ea lithethefatsi, kalafo ea opereishene le kalafo ea lefutso. Ka phekolo ea lithethefatsi, phenamidine e fumanoe e e-na le phello e ntle ho PD, e nang le chefo e tlaase le polokeho e ntle, 'me motsoako oa phenamidine o hloka tšebeliso ea 2,5-dimethoxybenzaldehyde e le ntho e qalang.

Ho ea ka mokhoa oa ho kopanya o tlalehiloeng libukeng, 2,5-dimethoxybenzaldehyde e fumanoa haholo-holo ka ho arabela 1,4-dimethoxybenzene ka moemeli oa formylation. Lisebelisoa tsa formylation li kenyelletsa (1) motsoako oa 1,1-dichloromethyl ether le titanium tetrachloride; (2) motsoako oa N, N-dimethylformamide le phosphorus oxychloride, motsoako oa N, N-dimethylformamide le oxalyl chloride; (3) motsoako oa N, N-dimethylformamide le thionyl chloride kapa motsoako oa urotropine le magnesium chloride. Leha ho le joalo, mekhoa ena e hloka tšebeliso ea tekanyo e ngata ea titanium tetrachloride, phosphorus oxychloride kapa thionyl chloride. Li-reagents tsena ha li tsitse ebile li senyeha habonolo, 'me palo e kholo ea khase ea hydrochloric acid e lokolloa nakong ea karabelo, e seng botsoalle ba tikoloho ebile e na le litlhoko tse phahameng bakeng sa ts'ebetso ea ts'ebetso.

Ho hlahisitsoe mokhoa o mocha oa ho kopanya. Mokhoa ona o sebelisa 1,4-dimethoxybenzene le formaldehyde e le lisebelisoa tse tala, 'me o etsa photooxidative coupling reaction ka pel'a oksijene le catalyst tlas'a mahlaseli a khanyang a maputsoa ho kopanya hantle 2,5-dimethoxybenzaldehyde. Mokhoa ona o sebelisa oksijene kapa moea e le oxidant, ha o hlahise khase e nang le asiti, hape o baballa tikoloho. Ho phaella moo, mokhoa ona o sebelisa cobalt e theko e tlaase e le mokelikeli, o theko e tlaase ebile o loketse ts'ebeliso ea indasteri.

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Re ikemiseditse ho fana ka tshebeletso e bonolo, e bolokang nako le ho boloka tjhelete e le nngwe feela bakeng sa bareki bakeng sa Dihlahiswa tsa Motho 2, 5-Dimethoxybenzaldehyde CAS 93-02-7, Khamphani ya rona e lebeletse ka tjantjello ho theha maqhama a nako e telele le a monate a balekane ba dikgwebo tse nyane le bareki le borakgwebo ho tswa hohle lefatsheng lohle.
Lihlahisoa tsa Motho93-02-7 le 2 5-Dimethoxybenzaldehyde, Re latela mokhoa o phahameng oa ho sebetsana le lihlahisoa tsena tse netefatsang ho tšoarella ka ho fetisisa le ho tšepahala ha lihlahisoa. Re latela mekhoa ea morao-rao e sebetsang ea ho hlatsoa le ho otlolla e re lumellang ho fana ka boleng bo ke keng ba lekanngoa ba lihlahisoa bakeng sa bareki ba rona. Re lula re hahamalla phetheho 'me boiteko bohle ba rona bo lebisitsoe molemong oa ho fumana khotsofalo e felletseng ea bareki.