litaba

Hydroxypropyl beta-cyclodextrin, e tsejoang hape e le (2-hydroxypropyl) -β-cyclodextrin, ke athomo ea haedrojene lihlopheng tsa 2-, 3-, le 6-hydroxyl tsa masala a tsoekere ho β-cyclodextrin (β-CD) e nkeloang sebaka ke hydroxypropyl ho ba hydroxypropoxy. HP-β-CD ha e na feela phello e ntle ea enfelopo metsoakong e mengata e kang β-CD, empa hape e na le melemo ea ho qhibiliha ha metsi a mangata le ho ntlafatsa sekhahla sa ho lokolloa le ho fumaneha ha meriana e kentsoeng ka har'a 'mele. Ho phaella moo, HP-β-CD ke mothusi oa lithethefatsi ea nang le data e pharaletseng ea polokeho e bokelletsoeng 'me ha e na litla-morao tse mpe. HP-β-CD e ka boela ea sebelisoa e le mosireletsi oa protheine le stabilizer.

Hydroxypropyl beta-cyclodextrin ke phofo e tšoeu kapa e tšoeu e sa fetoheng kapa e kristale; Ha e na monko, e monate hanyane; Ho kenngoa ha mongobo o matla. Sehlahisoa sena se qhibiliha habonolo metsing, se qhibiliha habonolo ka har'a methanol, ethanol, se batla se sa qhibilihe ka har'a acetone, trichloromethane.

Ho qhibiliha hahydroxypropyl-B-cyclodextrinKa metsing ho hotle haholo, 'me tekanyo ea ho nkeloa sebaka ea 4 le ho feta e ka kopanngoa le metsi ka tekanyo efe kapa efe, 'me e ka boela ea qhibiliha ka 50% ethanol le methanol. E na le hygroscopicity e itseng. Empa ts'ebetso ea bokaholimo le ts'ebetso ea hemolytic li tlase haholo. Ha e na ho teneha mesifa 'me ke sesebelisoa se setle sa ho matlafatsa solvent le se thusang meriana bakeng sa ente.

Hydroxypropyl beta-cyclodextrin e sebelisoa bakeng sa eng?

Lefapheng la lijo le linoko

Hydroxypropyl beta-cyclodextrin e ka ntlafatsa botsitso le ts'ebetso ea nako e telele ea limolek'hule tsa phepo e nepahetseng, ea koahela kapa ea lokisa monko o mobe le tatso ea limolek'hule tsa phepo e nepahetseng ea lijo, le ho ntlafatsa ts'ebetso ea tlhahiso le boleng ba sehlahisoa.

Ka litlolo

Lisebelisoa tse tala tsa litlolo li ka sebelisoa e le li-stabilizer, li-emulsifier, li-deodorizers, jj., tse ka fokotsang ho hlohlelletsoa ha limolek'hule tsa tlhaho litlolong letlalong le liseleng tsa mucous membrane, ho ntlafatsa botsitso ba metsoako e sebetsang, le ho thibela ho feto-fetoha ha moea le oxidation ea limatlafatsi. E na le hygroscopicity e itseng.

Lefapheng la bongaka

Hydroxypropyl beta-cyclodextrine ka ntlafatsa ho qhibiliha ha meriana e sa qhibiliheng metsing, ea eketsa botsitso ba meriana, ea ntlafatsa ho fumaneha ha meriana, ea eketsa katleho ea litokisetso tsa meriana kapa ea fokotsa tekanyo, ea lokisa kapa ea laola lebelo la ho lokolloa ha meriana, le ho fokotsa chefo ea meriana. E ka sebelisoa e le mojari oa meriana e nooang, ente, litsamaiso tsa ho fana ka meriana ka har'a mucosal (ho kenyeletsoa le mucosa ea nko, rectum, cornea, jj.), litsamaiso tsa ho fana ka meriana ka transdermal, meriana e shebaneng le lipophilic, 'me e ka boela ea sebelisoa e le mosireletsi le stabilizer ea protheine.