litaba

Hydroxypropyl beta-cyclodextrin, eo hape e tsejoang e le (2-hydroxypropyl) -β-cyclodextrin, ke athomo ea hydrogen ka har'a lihlopha tsa 2-, 3-, le 6-hydroxyl tsa masala a glucose ho β-cyclodextrin (β-CD) e nkeloang sebaka ke hydroxypropyl ho hydroxypropoxy. HP-β-CD ha e na phello e ntle ea enfelopo feela ho metsoako e mengata e kang β-CD, empa e boetse e na le melemo ea ho qhibiliha ha metsi a mangata le ho ntlafatsa sekhahla sa ho lokolloa le bioavailability ea lithethefatsi tse kentsoeng ka vivo. Ho feta moo, HP-β-CD ke sehlahisoa sa lithethefatsi se nang le lintlha tse ngata tsa polokeho tse bokelletsoeng 'me ha ho na litla-morao tse mpe. HP-β-CD e ka boela ea sebelisoa e le tšireletso ea protheine le stabilizer.

Hydroxypropyl beta-cyclodextrin ke phofo e tšoeu kapa e tšoeu ea amorphous kapa crystalline; Ha e na monko, e monate hanyenyane; Ho kenya mongobo ka matla. Sehlahisoa sena se qhibiliha habonolo ka metsing, se qhibiliha habonolo ka methanol, ethanol, hoo e ka bang ha se qhibilihe ka har'a acetone, trichloromethane.

The solubility eahydroxypropyl -B-cyclodextrinka metsing e ntle haholo, 'me tekanyo ea ho fetola ea 4 le ho feta e ka kopanngoa le metsi ka tekanyo leha e le efe,' me e ka boela ea qhibiliha ka 50% ea ethanol le methanol. E na le hygroscopicity e itseng. Empa ts'ebetso ea bokaholimo le ts'ebetso ea hemolytic e tlase haholo. Ha e na ho teneha mesifa 'me ke sehlahisoa se loketseng sa solvent le motsoako oa meriana bakeng sa ente.

Hydroxypropyl beta-cyclodextrin e sebelisetsoa eng?

Tšimong ea lijo le linoko

Hydroxypropyl beta-cyclodextrin e ka ntlafatsa botsitso le ts'ebetso ea nako e telele ea limolek'hule tsa phepo e nepahetseng, ho koahela kapa ho lokisa monko o mobe le tatso ea limolek'hule tsa phepo ea lijo, le ho ntlafatsa ts'ebetso ea tlhahiso le boleng ba sehlahisoa.

Ka litlolo

Lisebelisoa tse tala tsa litlolo li ka sebelisoa e le li-stabilizers, emulsifiers, deodorizers, joalo-joalo, tse ka fokotsang ho tsosoa ha limolek'hule tsa tlhaho ka har'a litlolo letlalong le liseleng tsa mucous, ho matlafatsa botsitso ba metsoako e sebetsang, le ho thibela ho senyeha le oxidation ea limatlafatsi. . E na le hygroscopicity e itseng e amanang le eona.

Lefapheng la bongaka

Hydroxypropyl beta-cyclodextrine ka ntlafatsa ho qhibiliha ha metsi ha lithethefatsi tse sa tsitsang, ho eketsa botsitso ba lithethefatsi, ho ntlafatsa bioavailability ea lithethefatsi, ho eketsa katleho ea litokisetso tsa lithethefatsi kapa ho fokotsa litekanyetso, ho fetola kapa ho laola lebelo la ho lokolloa ha lithethefatsi, le ho fokotsa chefo ea lithethefatsi. E ka sebelisoa e le sejari sa lithethefatsi tsa molomo, liente, litsamaiso tsa phepelo ea lithethefatsi tsa mucosal (ho kenyeletsoa nasal mucosa, rectum, cornea, joalo-joalo), litsamaiso tsa phepelo ea lithethefatsi tsa transdermal, lithethefatsi tse lebisitsoeng ho lipophilic, hape li ka sebelisoa e le mosireletsi oa protheine. stabilizer.