Fektheri ea Chaena bakeng sa Moetsi oa Meriana ea Mahareng, Mofani oa Meriana ea Mahareng, Mofani oa Phofo ea Prilocaine ea Boemo bo Holimo

Meputso ea rona ke ho fokotsa litheko tsa thekiso, sehlopha se matla sa lekeno, QC e ikhethileng, lifeme tse tiileng, lits'ebeletso tsa boleng bo holimo bakeng sa Fektheri ea Chaena bakeng sa Moetsi oa Meriana ea Bohareng, Mofani oa Meriana ea Bohareng, Mofani oa Phofo ea Prilocaine ea Boemo bo Holimo, re ka rarolla mathata a bareki ba rona kapele kamoo ho ka khonehang 'me ra etsa phaello bakeng sa bareki ba rona. Haeba u hloka k'hamphani e ntle le boleng bo holimo, ka kopo re khethe, kea leboha!
Meputso ea rona ke ho fokotsa litheko tsa thekiso, sehlopha se matla sa lekeno, QC e ikhethang, lifeme tse tiileng, lits'ebeletso tsa boleng bo holimo bakeng saLtd., Khamphani ea Theknoloji ea Wuhan Jingkang, Khamphani ea rona e nka "litheko tse utloahalang, nako e sebetsang hantle ea tlhahiso le tšebeletso e ntle ea kamora thekiso" e le molao-motheo oa rona. Re tšepa ho sebelisana le bareki ba bangata bakeng sa nts'etsopele le melemo e kopanetsoeng. Re amohela bareki ba ka bang teng ho ikopanya le rona.

2,5-Dimethoxybenzaldehydeke phofo e kristale e mosehla o bobebe e nang le boima ba limolek'hule ba 166.18 le ntlha e belang ea 146°C. E qhibiliha ka har'a metsoako ea lintho tse phelang e kang ethanol le ether. E sebelisoa haholo-holo e le motsoako oa meriana.

Ntle le ho oxidized kapa ho fokotsoa ho 2,5-dimethoxybenzoic acid, benzonitrile kapa benzyl alcohol,2,5-dimethoxybenzaldehydeka boyona e na le boleng bo ikhethang ba ts'ebeliso. Ka ho arabela le lintho tse nang le mefuta e fapaneng ea lihlopha tse sebetsang, limolek'hule tsa lithethefatsi tse nang le meaho e fapaneng le litlamorao tse fapaneng li ka fumanoa. Lefu la Parkinson (PD) ke lefu le tloaelehileng la methapo ea kutlo, 'me matšoao a lona a mantlha a kliniki a kenyelletsa ho thothomela ha mesifa, ho se tsitse, mathata a ho sisinyeha, boemo ba' mele le mathata a ho leka-lekana ha motsamao. Nts'etsopele e eketsehileng e tla boela e lebise tlhokomelong, kutloisisong, mathata a ho hopola le ho lahleheloa ke kelello ho totobetseng. Hona joale, kalafo ea PD e kenyelletsa haholo-holo phekolo ea lithethefatsi, kalafo ea opereishene le phekolo ea liphatsa tsa lefutso. Phekolong ea lithethefatsi, phenamidine e fumanoe e na le phello e ntle ho PD, ka chefo e tlase le polokeho e ntle, 'me tlhahiso ea phenamidine e hloka tšebeliso ea2,5-dimethoxybenzaldehydee le thepa ea ho qala.

Ho ya ka mokhoa wa ho kopanya o tlalehilweng dingolweng,2,5-dimethoxybenzaldehydee fumanoa haholo-holo ka ho sebetsana le 1,4-dimethoxybenzene ka moemeli oa formylation. Li-formylation agents li kenyelletsa (1) motsoako oa 1,1-dichloromethyl ether le titanium tetrachloride; (2) motsoako oa N,N-dimethylformamide le phosphorus oxychloride, motsoako oa N,N-dimethylformamide le oxalyl chloride; (3) motsoako oa N,N-dimethylformamide le thionyl chloride kapa motsoako oa urotropine le magnesium chloride. Leha ho le joalo, mekhoa ena e hloka tšebeliso ea tekanyo e kholo ea titanium tetrachloride, phosphorus oxychloride kapa thionyl chloride. Li-reagent tsena ha li tsitse ebile lia bola habonolo, 'me khase e ngata ea hydrochloric acid e lokolloa nakong ea karabelo, e seng mosa tikolohong 'me e na le litlhoko tse phahameng bakeng sa ts'ebetso ea ts'ebetso.

Mokhoa o mocha oa ho kopanya o se o sisintswe. Mokhoa ona o sebelisa 1,4-dimethoxybenzene le formaldehyde e le thepa e tala, 'me o etsa karabelo ea ho kopanya ka photooxidative moo oksijene le catalyst li leng teng tlas'a mahlaseli a khanya e putsoa ho kopanya 2,5-dimethoxybenzaldehyde ka katleho. Mokhoa ona o sebelisa oksijene kapa moea e le oxidant, ha o hlahise khase e nang le asiti, 'me o mosa tikolohong. Ho phaella moo, mokhoa ona o sebelisa cobalt e theko e tlaase e le catalyst, e theko e tlase 'me e loketse ts'ebeliso ea indasteri.

25kgs/moropa, 9tons/20'container

25kgs/mokotla, 20tons/20'container

Meputso ea rona ke ho fokotsa litheko tsa thekiso, sehlopha se matla sa lekeno, QC e ikhethileng, lifeme tse tiileng, lits'ebeletso tsa boleng bo holimo bakeng sa Fektheri ea Chaena bakeng sa Moetsi oa Meriana ea Bohareng, Mofani oa Meriana ea Bohareng, Mofani oa Phofo ea Prilocaine ea Boemo bo Holimo, re ka rarolla mathata a bareki ba rona kapele kamoo ho ka khonehang 'me ra etsa phaello bakeng sa bareki ba rona. Haeba u hloka k'hamphani e ntle le boleng bo holimo, ka kopo re khethe, kea leboha!
Feme ea Chaena bakeng saKhamphani ea Theknoloji ea Wuhan Jingkang, Ltd, Khamphani ea rona e nka "litheko tse utloahalang, nako e sebetsang hantle ea tlhahiso le tšebeletso e ntle ea kamora thekiso" e le molao-motheo oa rona. Re tšepa ho sebelisana le bareki ba bangata bakeng sa nts'etsopele le melemo e kopanetsoeng. Re amohela bareki ba ka bang teng ho ikopanya le rona.